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大鼠结节-垂体系统中的免疫反应性P物质:脱水和钠负荷后神经叶中的选择性减少。

Immunoreactive substance P in the tubero-hypophyseal system of the rat: selective decrease in the neural lobe after dehydration and sodium loading.

作者信息

Holzbauer M, Donnerer J, Holzer P, Schluet W, Lembeck F, Sharman D F

出版信息

Neurosci Lett. 1984 Jun 1;47(1):23-8. doi: 10.1016/0304-3940(84)90380-x.

DOI:10.1016/0304-3940(84)90380-x
PMID:6205329
Abstract

In the tubero-hypophyseal system of the rat the approximate concentrations of immunoreactive substance P (I-SP), expressed as fmol/mg tissue, were 100 in the medial basal hypothalamus (MBH), 20 in the anterior lobe (AL), 20 in the neural lobe (NL) and 4 in the intermediate lobe of the hypophysis. These values were not altered by treatment with capsaicin on day 2 after birth. In rats in which the secretion of neurohormones from the NL was increased by dehydration followed by sodium loading there was a fall by 70% in the I-SP concentration of the NL; no change occurred in the AL or the MBH.

摘要

在大鼠的结节-垂体系统中,以fmol/mg组织表示的免疫反应性P物质(I-SP)的近似浓度,在内侧基底下丘脑(MBH)中为100,在前叶(AL)中为20,在神经叶(NL)中为20,在垂体中间叶中为4。出生后第2天用辣椒素处理并未改变这些值。在通过脱水继以钠负荷使NL中神经激素分泌增加的大鼠中,NL的I-SP浓度下降了70%;AL或MBH中未发生变化。

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