Valente M
Appl Pathol. 1983;1(5):251-63.
In the 10-year period 1972-1981, 35 cardiac myxomas from 34 patients were studied. 29 tumors were surgical specimens and 6 were necropsy observations. No patient was under 10 years and only 3 were in the second decade. 25 growths were located in the left atrium, 6 in the right atrium and 2 in the right ventricle; 1 patient presented with myxomas involving both atria. The surface examined in 31 tumors appeared villous in 15, smooth in 13 and slightly irregular in 3. The tumor cells were enmeshed in Alcian blue positive mucoid material and presented as isolated, aggregated in clusters or in small cords, or lining vascular-like spaces. Ultrastructural examination performed in 9 cases disclosed a few features of endothelial cells: microvilli, cell interdigitations, desmosomes and pinocytotic vesicles; cytoplasmic organelles were usually more numerous in the cells arranged in clusters and lining spaces than in those isolated or in small cords; well-developed Golgi complex and endoplasmic reticulum were frequently observed and suggest a secretory function for the myxoma cells. The findings herein reported together with those of recent cytochemical studies support a mesenchymal origin for the myxoma cells with differentiation to endothelial line.
在1972年至1981年的10年期间，对34例患者的35个心脏黏液瘤进行了研究。29个肿瘤为手术标本，6个为尸检观察结果。患者年龄均在10岁以上，仅3例在20岁年龄段。25个肿瘤位于左心房，6个位于右心房，2个位于右心室；1例患者的黏液瘤累及两个心房。31个肿瘤的检查表面，15个呈绒毛状，13个光滑，3个略不规则。肿瘤细胞包埋在阿利新蓝阳性的黏液样物质中，呈孤立状态、聚集成团或呈小条索状，或衬于类血管腔隙内。对9例进行的超微结构检查揭示了一些内皮细胞的特征：微绒毛、细胞交错、桥粒和吞饮小泡；成簇排列并衬于腔隙内的细胞中的细胞质细胞器通常比孤立或呈小条索状的细胞中的更多；经常观察到发达的高尔基体和内质网，提示黏液瘤细胞具有分泌功能。本文报道的结果与近期细胞化学研究的结果共同支持黏液瘤细胞起源于间充质并向内皮细胞系分化的观点。
