Shigematsu N, Emori K, Matsuba K, Harada S, Takahashi T
Chest. 1978 Feb;73(2):186-8. doi: 10.1378/chest.73.2.186.
In 101 patients with histopathologic and clinical features compatible with sarcoidosis, a radiologic acinar pattern occurred in about 20% and was always accompanied by bilateral hilar lymphadenopathy. The radiologically acinar pattern histopathologically revealed noncaseating epithelioid granulomas and accumulations of macrophages in the alveolar spaces. Blood vessels were usually not affected by granulomas. On the other hand, a reticulonodular pattern histopathologically showed granulomas with centrally situated veins. The acinar form seems to represent the early stage of pulmonary sarcoldosis, producing primarily intra-alveolar lesions.
在101例具有与结节病相符的组织病理学和临床特征的患者中，约20%出现放射学腺泡型，且总是伴有双侧肺门淋巴结肿大。放射学腺泡型在组织病理学上显示为非干酪样上皮样肉芽肿以及肺泡腔内巨噬细胞聚集。血管通常不受肉芽肿影响。另一方面，网状结节型在组织病理学上显示肉芽肿中央有静脉。腺泡型似乎代表肺结节病的早期阶段，主要产生肺泡内病变。
