van Niekerk J L, Hendriks T, Gevers Leuven J A, Havekes L, de Boer H H
Clin Sci (Lond). 1984 Oct;67(4):439-44. doi: 10.1042/cs0670439.
The effect of 3-hydroxy-3-methylglutaric acid (HMG) on serum cholesterol levels was investigated in Watanabe heritable hyperlipidaemic (WHHL) rabbits. Oral administration of HMG resulted in a reduction of serum cholesterol by 39%. Bile acid drainage, by means of either cholestyramine medication or partial ileal bypass (PIB) surgery, also led to significant reductions in circulating cholesterol, by 35 and 59% respectively. Intraperitoneal injection of HMG after PIB surgery further reduced serum cholesterol by 35%. Fibroblasts from the WHHL rabbits did not show high-affinity binding, uptake or degradation of 125I-labelled low density lipoprotein (LDL). The working mechanism of these lipid-lowering lowering therapies in WHHL rabbits is discussed in relation to recent literature. The significant reductions in circulating cholesterol induced by HMG warrant further investigation into the use of this compound in the management of familial hypercholesterolaemia.
在渡边遗传性高脂血症（WHHL）兔中研究了3-羟基-3-甲基戊二酸（HMG）对血清胆固醇水平的影响。口服HMG可使血清胆固醇降低39%。通过消胆胺药物治疗或部分回肠旁路（PIB）手术进行胆汁酸引流，也分别使循环胆固醇显著降低35%和59%。PIB手术后腹腔注射HMG可使血清胆固醇进一步降低35%。WHHL兔的成纤维细胞未显示出对125I标记的低密度脂蛋白（LDL）的高亲和力结合、摄取或降解。结合近期文献讨论了这些降脂疗法在WHHL兔中的作用机制。HMG引起的循环胆固醇显著降低值得进一步研究该化合物在家族性高胆固醇血症管理中的应用。
