van Niekerk J L, Hendriks T, de Boer H H
Eur Surg Res. 1984;16(5):282-7. doi: 10.1159/000128420.
The effects of bile acid drainage on serum cholesterol levels have been investigated in Watanabe heritable hyperlipidemic rabbits, a unique model for homozygous familial hypercholesterolemia. Cholestyramine medication lowered serum cholesterol concentrations with 38%, while a 33% and a 50% small bowel bypass resulted in a decrease of 56 and 48%, respectively. Cholestyramine treatment after either bypass induced a minor additional fall in serum cholesterol. Ileal bypass and ileal resection were equally effective in reducing serum cholesterol. These results indicate the necessity for further investigation into the potential of bile acid drainage as a therapy in homozygous familial hypercholesterolemia.
在渡边遗传性高脂血症兔（一种纯合子家族性高胆固醇血症的独特模型）中，研究了胆汁酸引流对血清胆固醇水平的影响。消胆胺治疗使血清胆固醇浓度降低了38%，而33%和50%的小肠旁路手术分别导致血清胆固醇降低56%和48%。在任何一种旁路手术后进行消胆胺治疗，会使血清胆固醇进一步出现轻微下降。回肠旁路手术和回肠切除术在降低血清胆固醇方面同样有效。这些结果表明，有必要进一步研究胆汁酸引流作为纯合子家族性高胆固醇血症治疗方法的潜力。
