Nerlich A G, Nerlich M L, Joachim H, Müller P K
Eur J Clin Invest. 1984 Jun;14(3):190-8. doi: 10.1111/j.1365-2362.1984.tb01122.x.
We analysed the composition of parenchymal lung tissue from eleven multiply injured patients who died of protracted respiratory failure after an accident and six normal lungs. Lung wet and dry weights, protein, DNA, RNA and collagen amounts were determined in the lungs. Concentrations per dry weight of all parameters revealed only minor changes. Since there was a marked, time-dependent increase in both wet and dry weight, total lung contents of all components showed highly significant increases with survival time. Protein and RNA contents were elevated linearly in all patients, whereas DNA and collagen increased only in patients surviving more than 2 weeks. No correlation existed between biochemical data and a morphological fibrosis score, while morphometrically estimated cellularity and DNA concentration agreed well. Our results provide evidence that the reparative process for lung injury associated with traumatic shock is a tissue remodelling involving all tissue components in the long run.
我们分析了11例因事故导致长期呼吸衰竭死亡的多发伤患者以及6个正常肺的肺实质组织成分。测定了肺的湿重和干重、蛋白质、DNA、RNA及胶原蛋白含量。所有参数的干重浓度仅显示出微小变化。由于湿重和干重均有明显的、随时间的增加，所有成分的肺总含量随生存时间呈现高度显著增加。所有患者的蛋白质和RNA含量呈线性升高，而DNA和胶原蛋白仅在存活超过2周的患者中增加。生化数据与形态学纤维化评分之间不存在相关性，而形态计量学估计的细胞密度与DNA浓度吻合良好。我们的结果表明，创伤性休克相关肺损伤的修复过程从长远来看是一个涉及所有组织成分的组织重塑过程。
