Last J A, Siefkin A D, Reiser K M
Thorax. 1983 May;38(5):364-8. doi: 10.1136/thx.38.5.364.
Collagen in lung tissue was examined from patients with adult respiratory distress syndrome, from patients who did not have this disease but required mechanical ventilation and oxygen treatment, and from patients without overt lung disease. Cyanogen bromide peptide mapping techniques were used to determine the ratio of type I to type III collagen present in these lungs. In the fibrotic lungs from patients with adult respiratory distress syndrome a shift was found in the ratio of type I to type III from the normal value of 2:1 to a mean value of 3.4:1. In patients with normal lungs and those with other lung diseases collagen type ratios were normal. Our data suggest that (i) changes in lung collagen of patients with adult respiratory distress syndrome resemble those previously described in patients with idiopathic pulmonary fibrosis, although the changes occur much more rapidly in the former; (ii) the increased content of collagen in lungs of patients with adult respiratory distress syndrome shown by others is predominantly of type I collagen; and (iii) the stimulus to the lung to produce excess type I collagen relative to type III is not solely of iatrogenic origin--that is, resulting from oxygen or ventilator treatment.
对患有成人呼吸窘迫综合征的患者、未患此病但需要机械通气和氧气治疗的患者以及无明显肺部疾病的患者的肺组织中的胶原蛋白进行了检测。使用溴化氰肽图谱技术来确定这些肺中I型胶原与III型胶原的比例。在患有成人呼吸窘迫综合征的患者的纤维化肺中，发现I型与III型的比例从正常的2:1转变为平均3.4:1。在肺正常的患者和患有其他肺部疾病的患者中，胶原类型比例正常。我们的数据表明：（i）成人呼吸窘迫综合征患者肺胶原蛋白的变化类似于先前在特发性肺纤维化患者中描述的变化，尽管前者变化发生得更快；（ii）其他人所显示的成人呼吸窘迫综合征患者肺中胶原蛋白含量增加主要是I型胶原；（iii）相对于III型，刺激肺产生过量I型胶原的因素并非完全是医源性的——即并非由氧气或呼吸机治疗导致。
