Nikkinen A, Lehtosalo J I, Uusitalo H, Palkama A, Panula P
Histochemistry. 1984;81(1):23-7. doi: 10.1007/BF00495396.
Two neuropeptides, substance P and vasoactive intestinal polypeptide, have been shown to increase secretion of exocrine glands. We have studied immunohistochemically the intra- and exorbital lacrimal glands of the rat and the guinea pig for the presence of substance P-like and vasoactive intestinal polypeptide-like immunoreactive (SPLI and VIPLI, respectively) nerve fibers. Both SPLI and VIPLI nerve fibers were found surrounding glandular acini, secretory ducts and blood vessels. Their distribution, however, was uneven. The SPLI fibers predominated around the ducts whereas VIPLI fibers predominated around acini. The results suggest that the two neuropeptides may both regulate the lacrimal secretion, but they may have two different sites of actions because they prevail in different locations.
两种神经肽，即P物质和血管活性肠多肽，已被证明可增加外分泌腺的分泌。我们采用免疫组织化学方法研究了大鼠和豚鼠眼眶内和眶外泪腺中是否存在P物质样和血管活性肠多肽样免疫反应性（分别为SPLI和VIPLI）神经纤维。发现SPLI和VIPLI神经纤维均围绕腺泡、分泌导管和血管分布。然而，它们的分布并不均匀。SPLI纤维在导管周围占主导，而VIPLI纤维在腺泡周围占主导。结果表明，这两种神经肽可能都调节泪液分泌，但它们可能有两个不同的作用位点，因为它们在不同位置占优势。
