Allinquant B, Musenger C, Schuller E
Acta Neurol Scand. 1984 Jul;70(1):12-9.
A CSF Poly(C)-avid ribonuclease (RNase) activity was determined in serum and CSF of 11 controls and 75 neurological patients (34 multiple sclerosis (MS), 18 infectious processes and 23 other neurological diseases (OND]. In controls, the blood-CSF ratio of RNase activity is low. This fact and the absence of correlation between serum and CSF RNase activity (except in OND group), and between CSF albumin and CSF RNase activity in controls and MS patients, suggest an intrathecal origin for the major part of this CSF RNase activity. A formula taking into account any plasmatic enrichment in RNase of the CSF is proposed to evaluate this intrathecal activity. The normal mean value of this intrathecal RNase activity is 27 +/- 3 units/ml (mean +/- SE) in our experimental conditions and using our formula. The highest intrathecal RNase activity is observed in infectious processes and this finding is associated with a significant increase in the local anti-RNA antibody synthesis. An increase in intrathecal RNase activity is rarely found in MS and local anti-RNA synthesis is only observed in one third of MS patients.
在11名对照者和75名神经系统疾病患者（34例多发性硬化症（MS）、18例感染性疾病和23例其他神经系统疾病（OND））的血清和脑脊液中测定了脑脊液聚（C）-avid核糖核酸酶（RNase）活性。在对照者中，RNase活性的血脑脊液比值较低。这一事实以及血清与脑脊液RNase活性之间（OND组除外）以及对照者和MS患者脑脊液白蛋白与脑脊液RNase活性之间缺乏相关性，提示该脑脊液RNase活性的主要部分起源于鞘内。提出了一个考虑脑脊液中RNase任何血浆富集情况的公式来评估这种鞘内活性。在我们的实验条件下并使用我们的公式，这种鞘内RNase活性的正常平均值为27±3单位/毫升（平均值±标准误）。在感染性疾病中观察到最高的鞘内RNase活性，这一发现与局部抗RNA抗体合成的显著增加有关。在MS中很少发现鞘内RNase活性增加，仅在三分之一的MS患者中观察到局部抗RNA合成。
