Kiyosawa H, Sugawara C, Sugawara N, Miyake H
Am J Clin Nutr. 1984 Sep;40(3):479-84. doi: 10.1093/ajcn/40.3.479.
Three groups of male Japanese rabbits weighing about 2.7 kg each were given experimental diets consisting of high cholesterol food and fluid skim milk, yogurt, or water, and were bled every 4 wk to measure serum lipids. After 12 wk they were killed and concentrations of total cholesterol and atheromatous areas dyed with Oil Red O were determined in the aorta to evaluate the development of atherosclerosis. At 8 and 12 wk, the skim milk group showed significantly lower levels of serum total cholesterol, low-density lipoprotein cholesterol, and triglyceride than the control group. Although no significant difference between the yogurt and control groups in the concentration of serum lipids was observed, total cholesterol concentrations in the aorta were significantly lower in both the skim milk and the yogurt groups than in the control group. The atheromatous areas of the skim milk group (38 +/- 34%) were significantly smaller than those of the control group (75 +/- 25%). Significant difference, however, was not found between the yogurt group (51 +/- 22%) and the control group. Concentrations of total cholesterol in the liver did not differ among the three groups. These results suggest that skim milk may have a preventive effect on the development of atherosclerosis.
将三组体重约2.7千克的雄性日本兔分别喂食由高胆固醇食物和流质脱脂牛奶、酸奶或水组成的实验性饮食，每4周采血一次以测量血脂。12周后将它们处死，测定主动脉中总胆固醇浓度以及用油红O染色的动脉粥样硬化区域，以评估动脉粥样硬化的发展情况。在第8周和第12周时，脱脂牛奶组的血清总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平显著低于对照组。虽然未观察到酸奶组和对照组在血脂浓度上有显著差异，但脱脂牛奶组和酸奶组主动脉中的总胆固醇浓度均显著低于对照组。脱脂牛奶组的动脉粥样硬化区域（38±34%）显著小于对照组（75±25%）。然而，酸奶组（51±22%）和对照组之间未发现显著差异。三组肝脏中的总胆固醇浓度没有差异。这些结果表明，脱脂牛奶可能对动脉粥样硬化的发展具有预防作用。
