Langer R, Murray J
Appl Biochem Biotechnol. 1983 Feb;8(1):9-24. doi: 10.1007/BF02798344.
The extensive vascularity of solid tumors has been recognized for over 100 yr (1). However, only in the past 15 yr has the importance of this phenomenon been appreciated and only in the past 6 yr has the possibility of chemical interference been apparent. In this article, we review the emerging field of tumor vascularization inhibitors.