帕金森病中的反应时间与警觉性。去甲肾上腺素代谢改变的可能作用。

Reaction time and vigilance in Parkinson's disease. Possible role of altered norepinephrine metabolism.

作者信息

Stern Y, Mayeux R, Côté L

出版信息

Arch Neurol. 1984 Oct;41(10):1086-9. doi: 10.1001/archneur.1984.04050210084021.

DOI:10.1001/archneur.1984.04050210084021

PMID:6206831

Abstract

Delayed reaction time and diminished vigilance have been observed in Parkinson's disease (PD) but have not been related to biochemical changes in the disease. As norepinephrine is reduced in the brain in PD and this neurotransmitter has been related to attention and learning, we investigated the relationship of neuropsychological measures, including those of reaction time and vigilance, to the norepinephrine metabolite 3-methoxy - 4 - hydroxyphenethyleneglycol (MHPG) in 39 patients with idiopathic PD. The MHPG levels correlated with a measure of general intellectual ability and with performance on reaction time and continuous performance tasks. Our data suggest that altered norepinephrine metabolism may contribute to some aspects of intellectual dysfunction in PD.

摘要

帕金森病（PD）患者存在反应时间延迟和警觉性降低的情况，但这些与该疾病的生化变化并无关联。由于帕金森病患者大脑中的去甲肾上腺素减少，且这种神经递质与注意力和学习有关，我们对39例特发性帕金森病患者进行了研究，以探讨神经心理学指标（包括反应时间和警觉性指标）与去甲肾上腺素代谢产物3-甲氧基-4-羟基苯乙二醇（MHPG）之间的关系。MHPG水平与一般智力能力指标以及反应时间和连续操作任务的表现相关。我们的数据表明，去甲肾上腺素代谢改变可能导致帕金森病患者智力功能障碍的某些方面。