Selective attention in Alzheimer's disease: CSF correlates of behavioral impairments.
作者信息
Freed D M, Corkin S, Growdon J H, Nissen M J
机构信息
Department of Psychology and Clinical Research Center, Massachusetts Institute of Technology, Cambridge 02139.
出版信息
Neuropsychologia. 1988;26(6):895-902. doi: 10.1016/0028-3932(88)90057-7.
PMID:2461537
Abstract
CSF levels of HVA, 5-HIAA, and free MHPG, the major metabolites of dopamine, serotonin, and norepinephrine respectively, were measured in 22 patients with AD. These 22 patients were also administered tests of picture-recognition and attentional focusing as part of an earlier experiment. A significant association between deficits in attentional focusing and reduced levels of free MHPG in CSF was noted. These results suggest that behavioral measures can identify patients with noradrenergic involvement.
摘要
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