短杆菌肽A单通道电导分散性的来源。亮氨酸-X-亮氨酸5-短杆菌肽A类似物。
The source of the dispersity of gramicidin A single-channel conductances. The L X Leu5-gramicidin A analog.
作者信息
Urry D W, Alonso-Romanowski S, Venkatachalam C M, Trapane T L, Prasad K U
出版信息
Biophys J. 1984 Aug;46(2):259-65. doi: 10.1016/S0006-3495(84)84019-9.
Abstract
The L X Leu5-gramicidin A analog has been designed, synthesized, and verified for the purpose of testing the perspective that different side-chain distributions are responsible for the dispersity of single-channel conductances. The structural analysis shows that the L . Leu5 analog would limit the possible number of side-chain distributions and that the dispersity of channel conductances would decrease. The finding is the expected decrease in less probable conductance states and the associated increase in the probability of the most probable conductance state.
摘要
设计、合成并验证了L X Leu5-短杆菌肽A类似物，以检验不同侧链分布导致单通道电导分散性这一观点。结构分析表明，L.Leu5类似物会限制侧链分布的可能数量，并且通道电导的分散性会降低。这一发现是不太可能的电导状态预期减少，以及最可能的电导状态概率相应增加。
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2
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