Kohno J, Shiosaka S, Shinoda K, Inagaki S, Tohyama M
Brain Res. 1984 Aug 13;308(2):309-17. doi: 10.1016/0006-8993(84)91070-9.
Re-examination of the strio-nigral substance P (SP) tract by means of an experimental immunohistochemical method in the rats demonstrated the presence of two distinct pathways from the nucleus caudatus putamen (CP) to the substantia nigra (SN). Destruction of the posterior portion of the CP resulted in the disappearance of SP-positive fibers in the SN pars lateralis but not in the SN pars compacta or reticulata. On the other hand, destruction of the ventrolateral portion of the anterior portion of the CP caused the disappearance of SP-positive fibers in the SN pars compacta and pars reticulata but not in the SN pars lateralis. In addition, destruction of the dorsal portion of the anterior portion of the CP, where 3-6 cell islets of SP-positive cells are located, failed to decrease SP-positive fibers in any of the subdivisions of the SN. These findings strongly suggest that SP-positive neurons in the posterior portion of the CP project to the SN pars lateralis (posterior strio-nigral SP tract), SP-positive cells in the lateroventral part of the anterior portion of the CP extend to the SN pars compacta and pars reticulata, but SP-positive cells in the dorsal part of the anterior portion of the CP do not innervate the SN.
通过实验性免疫组织化学方法对大鼠纹状体黑质P物质（SP）通路进行重新检查，结果表明从尾壳核（CP）到黑质（SN）存在两条不同的通路。破坏CP的后部会导致SN外侧部的SP阳性纤维消失，但在SN致密部或网状部不会消失。另一方面，破坏CP前部的腹外侧部分会导致SN致密部和网状部的SP阳性纤维消失，但在SN外侧部不会消失。此外，破坏CP前部的背侧部分（此处有3 - 6个SP阳性细胞胰岛），未能减少SN任何亚区的SP阳性纤维。这些发现有力地表明，CP后部的SP阳性神经元投射到SN外侧部（后部纹状体黑质SP通路），CP前部腹外侧部分的SP阳性细胞延伸到SN致密部和网状部，但CP前部背侧部分的SP阳性细胞不支配SN。
