用杂交瘤抗体鉴定的A群链球菌M蛋白不同血清型之间独特且共有的保护性表位。
Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies.
作者信息
Dale J B, Beachey E H
出版信息
Infect Immun. 1984 Oct;46(1):267-9. doi: 10.1128/iai.46.1.267-269.1984.
Abstract
A set of four monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the four antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially "rheumatogenic" serotypes.
摘要
制备了一组针对5型链球菌M蛋白高度纯化胃蛋白酶提取物的四种单克隆抗体。四种抗体中的三种与来自异源血清型的纯化M蛋白发生交叉反应，并调理相应的异源生物体。我们的研究表明，单克隆抗体可能有助于鉴定各种M蛋白的亚肽，这些亚肽含有共同的保护性表位，能够诱发可抵御几种不同潜在“致风湿性”血清型的抗体。
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