Hersey P, Edwards A
Int J Immunopharmacol. 1984;6(4):315-20. doi: 10.1016/0192-0561(84)90048-1.
Addition of isoprinosine to cultures of blood mononuclear cells was shown to inhibit natural killer (NK) cell activity against the K562 myeloid cells and melanoma cells. This appeared to be due to inhibitory influences of monocytes in that after removal of adherent cells isoprinosine appeared to stimulate NK activity. Similar effects were noted on T cells separated by E rosette procedures. Administration of isoprinosine in vivo had variable effects on NK activity during drug administration but there was a significant increase in NK activity 3 days after cessation of the drug. These changes in NK activity may reflect different threshold levels of the drug on suppressor and NK cell populations and the relative proportions of different lymphocyte populations in individual subjects. Further studies with a wider range of drug doses and more frequent monitoring of responses are required to further evaluate the effect of isoprinosine on NK activity.
已证明，在血液单核细胞培养物中添加异丙肌苷可抑制自然杀伤（NK）细胞对K562髓样细胞和黑色素瘤细胞的活性。这似乎是由于单核细胞的抑制作用，因为去除贴壁细胞后，异丙肌苷似乎能刺激NK活性。在用E花环法分离的T细胞上也观察到了类似的效果。在体内给予异丙肌苷期间，对NK活性的影响各不相同，但在停药3天后，NK活性显著增加。NK活性的这些变化可能反映了该药物对抑制细胞和NK细胞群体的不同阈值水平，以及个体受试者中不同淋巴细胞群体的相对比例。需要进一步研究更广泛的药物剂量范围，并更频繁地监测反应，以进一步评估异丙肌苷对NK活性的影响。
