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香菇多糖在人体内的作用机制——II. 作为干扰素诱导剂增强非特异性细胞介导的细胞毒性

Acting mechanisms of Lentinan in human--II. Enhancement of non-specific cell-mediated cytotoxicity as an interferon inducer.

作者信息

Miyakoshi H, Aoki T, Mizukoshi M

出版信息

Int J Immunopharmacol. 1984;6(4):373-9. doi: 10.1016/0192-0561(84)90057-2.

DOI:10.1016/0192-0561(84)90057-2
PMID:6207124
Abstract

The immunopotentiator "Lentinan" augmented the cell-mediated cytotoxicity in humans. (a) The activation of killer T cells by the mixed lymphocyte culture was accelerated only when responder cells were mixed with both a suboptimum number of stimulator cells and Lentinan. (b) The interferon level in the peripheral blood circulation of cancer patients was elevated in 12 h following Lentinan administration, and natural killer activity of peripheral mononuclear cells was enhanced in 48 h. These data indicate that Lentinan favorably affects the host mechanisms of man.

摘要

免疫增强剂“香菇多糖”增强了人体的细胞介导细胞毒性。(a) 仅当反应细胞与亚最佳数量的刺激细胞和香菇多糖混合时,混合淋巴细胞培养对杀伤性T细胞的激活才会加速。(b) 香菇多糖给药后12小时,癌症患者外周血液循环中的干扰素水平升高,48小时后外周单核细胞的自然杀伤活性增强。这些数据表明香菇多糖对人体宿主机制有积极影响。

相似文献

1
Acting mechanisms of Lentinan in human--II. Enhancement of non-specific cell-mediated cytotoxicity as an interferon inducer.香菇多糖在人体内的作用机制——II. 作为干扰素诱导剂增强非特异性细胞介导的细胞毒性
Int J Immunopharmacol. 1984;6(4):373-9. doi: 10.1016/0192-0561(84)90057-2.
2
Effects of lentinan on cytotoxic functions of human lymphocytes.香菇多糖对人淋巴细胞细胞毒性功能的影响。
Immunopharmacol Immunotoxicol. 1988;10(2):157-63. doi: 10.3109/08923978809014330.
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[Studies on the effect of lentinan on human immune system. II. In vivo effect on NK activity, MLR induced killer activity and PHA induced blastic response of lymphocytes in cancer patients].
Gan To Kagaku Ryoho. 1983 Sep;10(9):2000-6.
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In vitro generation of activated natural killer cells and cytotoxic macrophages with lentinan.香菇多糖体外诱导活化自然杀伤细胞和细胞毒性巨噬细胞的生成。
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Acting mechanisms of Lentinan in human--I. Augmentation of DNA synthesis and immunoglobulin production of peripheral mononuclear cells.香菇多糖在人体中的作用机制——I. 增强外周血单个核细胞的DNA合成及免疫球蛋白产生
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Synergistic induction of lymphokine (IL-2)-activated killer activity by IL-2 and the polysaccharide lentinan, and therapy of spontaneous pulmonary metastases.白细胞介素-2(IL-2)与香菇多糖协同诱导淋巴因子激活的杀伤活性及对自发性肺转移的治疗
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Enhanced NK cell activity in mice injected with interferon and interferon inducers.在注射干扰素和干扰素诱导剂的小鼠中自然杀伤细胞活性增强。
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[The immunostimulating action of lactobacteria on the cytotoxicity of natural killer cells and interferon production].[乳酸菌对自然杀伤细胞细胞毒性和干扰素产生的免疫刺激作用]
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The preoperative administration of lentinan ameliorated the impairment of natural killer activity after cardiopulmonary bypass.术前给予香菇多糖可改善体外循环后自然杀伤活性的损害。
Int J Immunopharmacol. 1999 Aug;21(8):531-40. doi: 10.1016/s0192-0561(99)00033-8.
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Enhancement by interferon of natural killer cell activity in mice.
Cell Immunol. 1979 Apr;44(1):186-200. doi: 10.1016/0008-8749(79)90039-x.

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Anticancer Agents Med Chem. 2013 Jun;13(5):681-8. doi: 10.2174/1871520611313050002.
2
The effects of beta-glucan on human immune and cancer cells.β-葡聚糖对人类免疫细胞和癌细胞的影响。
J Hematol Oncol. 2009 Jun 10;2:25. doi: 10.1186/1756-8722-2-25.
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In vitro generation of activated natural killer cells and cytotoxic macrophages with lentinan.香菇多糖体外诱导活化自然杀伤细胞和细胞毒性巨噬细胞的生成。
Eur J Clin Pharmacol. 1992;42(6):623-7. doi: 10.1007/BF00265926.