Miyakoshi H, Aoki T
Int J Immunopharmacol. 1984;6(4):365-71. doi: 10.1016/0192-0561(84)90056-0.
The immunopotentiating activity and acting mechanisms of Lentinan were investigated in the human system, resulting in clarification of the following characteristics. (a) Augmentation of DNA synthesis of peripheral mononuclear cells (PMNC) occurred both in vitro and in vivo by adding or injecting Lentinan, for which the coexistence of T cells, B cells and adherent cells (mainly monocytes) was essential. (b) No additional mitogenic effect of Lentinan was observed when PMNC were incubated with both Lentinan and other mitogens. (c) In vitro production of immunoglobulin by PMNC induced with pokeweed mitogen was enhanced through the inhibition of suppressor T cell activity by Lentinan.
在人体系统中研究了香菇多糖的免疫增强活性及其作用机制，明确了以下特性。(a) 在体外和体内，通过添加或注射香菇多糖均可使外周单核细胞(PMNC)的DNA合成增加，其中T细胞、B细胞和黏附细胞(主要是单核细胞)的共存是必不可少的。(b) 当PMNC与香菇多糖和其他有丝分裂原一起孵育时，未观察到香菇多糖的额外促有丝分裂作用。(c) 香菇多糖通过抑制抑制性T细胞活性，增强了由商陆有丝分裂原诱导的PMNC体外免疫球蛋白产生。
