[111In]博来霉素及其组分在荷瘤小鼠体内的分布与稳定性
Distribution and stability of [111In]bleomycin and its fractions in tumor-bearing mice.
作者信息
Hou D Y, Hoch H, Johnston G S, Tsou K C, Farkas R J, Miller E E
出版信息
Int J Nucl Med Biol. 1984;11(2):129-39. doi: 10.1016/0047-0740(84)90048-2.
The tissue distributions in glioma-bearing mice given injections of [111In]bleomycin (BLM) indicated that tumor concentrations and ratios of tumor to blood, muscle and brain for [111In]BLM-B2 and -A2 were higher than those for unfractionated [111In]BLM. Autoradiographs of electrophoretic gels of urine containing [111In]BLM or one of its fractions differed from those containing 111InCl3. [111In]BLM and its fractions (A2 and B2) were found to be stable in vivo. The fractions may be more useful in the clinic than [111In]BLM.
给荷胶质瘤小鼠注射[111铟]博来霉素（BLM）后的组织分布表明，[111铟]BLM - B2和 - A2的肿瘤浓度以及肿瘤与血液、肌肉和脑的比率高于未分级的[111铟]BLM。含[111铟]BLM或其某一组分的尿液的电泳凝胶放射自显影片与含111氯化铟的不同。发现[111铟]BLM及其组分（A2和B2）在体内是稳定的。这些组分在临床上可能比[111铟]BLM更有用。
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