• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A monoclonal antibody which detects a 125 kd glycoprotein on embryonal carcinoma cells and is mitogenic for murine spleen cells.

作者信息

Stern P, Gilbert P, Sternberg S, Thompson S, Chada K

出版信息

J Reprod Immunol. 1984 Aug;6(5):313-28. doi: 10.1016/0165-0378(84)90030-5.

DOI:10.1016/0165-0378(84)90030-5
PMID:6207296
Abstract

The isolation and characterisation of a monoclonal antibody (2H9), selected for reactivity against murine teratocarcinoma stem cells, is described. This antibody recognizes one major glycoprotein on the surface of embryonal carcinoma (EC) cells but detects multiple glycoprotein species on various murine or human derived cell types. The binding of the antibody to cells is abolished by treatment with periodate or neuraminidase. These results suggest that 2H9 antibody detects a carbohydrate determinant; this is apparently distinct from other anti-EC reactive monoclonal antibodies and a variety of lectins. These antibodies are mitogenic for a population of lymphocytes in murine spleen. The antibodies recognize numerous cell surface glycoproteins on the surface of the spleen cells.

摘要

相似文献

1
A monoclonal antibody which detects a 125 kd glycoprotein on embryonal carcinoma cells and is mitogenic for murine spleen cells.
J Reprod Immunol. 1984 Aug;6(5):313-28. doi: 10.1016/0165-0378(84)90030-5.
2
Three monoclonal antibodies defining distinct differentiation antigens associated with different high molecular weight polypeptides on the surface of human embryonal carcinoma cells.三种单克隆抗体，它们定义了与人类胚胎癌细胞表面不同的高分子量多肽相关的独特分化抗原。
Hybridoma. 1984 Winter;3(4):347-61. doi: 10.1089/hyb.1984.3.347.
3
A monoclonal antibody which detects a cell surface antigen on murine embryonal carcinoma and early mouse embryo stages may recognize a carbohydrate determinant involving alpha-linked galactose.
J Reprod Immunol. 1983 May;5(3):145-60. doi: 10.1016/0165-0378(83)90012-8.
4
Two monoclonal antibodies recognizing determinants on human embryonal carcinoma cells react specifically with the liver isozyme of human alkaline phosphatase.两种识别人类胚胎癌细胞上决定簇的单克隆抗体与人碱性磷酸酶的肝脏同工酶发生特异性反应。
Hybridoma. 1984;3(1):33-9. doi: 10.1089/hyb.1984.3.33.
5
Developmentally regulated surface structures of teratocarcinoma stem cells studied by mutant cell lines.
Cell Differ. 1984 Dec;15(2-4):249-53. doi: 10.1016/0045-6039(84)90082-4.
6
The glycosidic antigen recognised by a novel monoclonal antibody, 75.12, is developmentally regulated on mouse embryonal carcinoma cells.一种新型单克隆抗体75.12所识别的糖苷抗原在小鼠胚胎癌细胞上受到发育调控。
EMBO J. 1983;2(12):2217-22. doi: 10.1002/j.1460-2075.1983.tb01726.x.
7
A pluripotent human stem-cell clone isolated from the TERA-2 teratocarcinoma line lacks antigens SSEA-3 and SSEA-4 in vitro, but expresses these antigens when grown as a xenograft tumor.从TERA-2畸胎瘤细胞系分离出的一个多能人类干细胞克隆在体外缺乏阶段特异性胚胎抗原-3（SSEA-3）和阶段特异性胚胎抗原-4（SSEA-4），但作为异种移植瘤生长时会表达这些抗原。
Differentiation. 1985;29(2):127-35. doi: 10.1111/j.1432-0436.1985.tb00305.x.
8
[The surface glycolipid antigen specific for the internal cell mass of the mouse blastocyst and of the stem cells of murine teratocarcinoma F9].[针对小鼠囊胚内细胞团和鼠畸胎瘤F9干细胞的表面糖脂抗原]
Ontogenez. 1989 Mar-Apr;20(2):158-63.
9
Analysis of the xenogeneic T-cell response to murine H-2 negative embryonal carcinoma cells.对小鼠H-2阴性胚胎癌细胞的异种T细胞反应分析。
Immunology. 1985 Mar;54(3):549-57.
10
Enrichment of rat NK cytotoxicity for H2-negative murine embryonal carcinoma cells by panning and short-term culture in TCGF.通过淘选法和在白细胞介素-2中短期培养，增强大鼠自然杀伤细胞对H2阴性小鼠胚胎癌细胞的细胞毒性。
Immunology. 1984 Sep;53(1):23-32.

引用本文的文献

1
Human ovarian tumour cells can bind hyaluronic acid via membrane CD44: a possible step in peritoneal metastasis.人类卵巢肿瘤细胞可通过膜CD44与透明质酸结合：这可能是腹膜转移的一个步骤。
Clin Exp Metastasis. 1996 Sep;14(4):325-34. doi: 10.1007/BF00123391.
2
Elevated levels of abnormally-fucosylated haptoglobins in cancer sera.癌症患者血清中异常岩藻糖基化触珠蛋白水平升高。
Br J Cancer. 1987 Nov;56(5):605-10. doi: 10.1038/bjc.1987.249.
3
A 72 kD trophoblast glycoprotein defined by a monoclonal antibody.一种由单克隆抗体界定的72千道尔顿滋养层糖蛋白。
Br J Cancer. 1988 Mar;57(3):239-46. doi: 10.1038/bjc.1988.53.
4
Trophoblast glycoprotein recognised by monoclonal antibody 5T4 maps to human chromosome 6q14-q15.被单克隆抗体5T4识别的滋养层糖蛋白定位于人类染色体6q14 - q15。
Hum Genet. 1990 Apr;84(5):455-8. doi: 10.1007/BF00195819.