蓝色葡聚糖结合并稳定人或小鼠干扰素的新衍生物。
New derivatives of blue dextran binding and stabilizing human or mouse interferons.
作者信息
Piasecki E, Popik W, Inglot A D, Konieczny M, Charytonowicz D
出版信息
Arch Immunol Ther Exp (Warsz). 1984;32(2):231-8.
PMID:6207796
Abstract
Mouse or human interferons were found to bind strongly to Blue Dextran 2000 and its eight new derivatives (compound VII to XIV covalently bound to Dextran 2000). The congeners of BD were pale violet or grey. The affinity of Blue Dextran and its congeners to interferons were: IFN-beta greater than IFN-alpha greater than IFN-gamma. The carriers stabilized the antiviral activity of beta-type of interferon during storage at 4 degrees C.
摘要
发现小鼠或人干扰素能与蓝色葡聚糖2000及其八种新衍生物（与葡聚糖2000共价结合的化合物VII至XIV）强烈结合。BD的同系物呈浅紫色或灰色。蓝色葡聚糖及其同系物对干扰素的亲和力为：IFN-β＞IFN-α＞IFN-γ。这些载体在4℃储存期间稳定了β型干扰素的抗病毒活性。
Zotero 插件