Cross A J, Crow T J, Ferrier I N, Johnson J A, Bloom S R, Corsellis J A
J Neurochem. 1984 Dec;43(6):1574-81. doi: 10.1111/j.1471-4159.1984.tb06081.x.
Serotonin receptors were assessed in post-mortem brains of control and Alzheimer-type dementia (ATD) patients using ligand binding techniques. Differential losses of serotonin S1 and S2 receptors were present in neocortex, hippocampus, and amygdala of ATD patients, whereas no significant changes were observed in basal forebrain and basal ganglia. Losses of S1 receptors were significantly age-related in the ATD group, suggesting they occurred at a later stage of the disease process. Losses of S2 receptors were considerably greater (with a reduction to 35% of control in temporal cortex) and were not age-related in ATD. Significant correlations were observed within the ATD group between S2 receptor binding and somatostatin immunoreactivity in temporal and frontal cortices. Thus the loss of S2 receptors in ATD may be a relatively early change in the disease process, and may precede the changes in ascending serotonergic neurones.
采用配体结合技术对对照组和阿尔茨海默型痴呆（ATD）患者的尸检大脑中的5-羟色胺受体进行了评估。ATD患者的新皮质、海马体和杏仁核中存在5-羟色胺S1和S2受体的差异性丢失，而在基底前脑和基底神经节中未观察到显著变化。ATD组中S1受体的丢失与年龄显著相关，表明它们发生在疾病进程的后期。S2受体的丢失程度更大（颞叶皮质中降至对照组的35%），且在ATD中与年龄无关。在ATD组中，颞叶和额叶皮质的S2受体结合与生长抑素免疫反应性之间存在显著相关性。因此，ATD中S2受体的丢失可能是疾病进程中相对较早的变化，可能先于上行5-羟色胺能神经元的变化。
