Cross A J, Crow T J, Ferrier I N, Johnson J A
Neurobiol Aging. 1986 Jan-Feb;7(1):3-7. doi: 10.1016/0197-4580(86)90019-9.
The high-affinity binding of thirteen ligands to putative neurotransmitter receptors was studied in temporal cortex of control and Alzheimer-type dementia (ATD) patients. A selective reduction of serotonin S2 receptors was observed in the ATD patients, to 57% of controls with no change in S1 receptors. Of the other ligand binding sites studied, only 3H-flunitrazepam binding was significantly reduced, to 84% of controls. Ligand binding sites which were unchanged in ATD temporal cortex included those labelled by adrenergic, adenosine, histamine, opiate, GABA, benzodiazepine and cholinergic ligands.
在对照患者和阿尔茨海默型痴呆（ATD）患者的颞叶皮质中，研究了13种配体与假定神经递质受体的高亲和力结合情况。在ATD患者中观察到血清素S2受体选择性减少，降至对照组的57%，而S1受体无变化。在所研究的其他配体结合位点中，只有3H-氟硝西泮结合显著减少，降至对照组的84%。在ATD颞叶皮质中未发生变化的配体结合位点包括那些由肾上腺素能、腺苷、组胺、阿片、GABA、苯二氮卓和胆碱能配体标记的位点。
