Chang L M, Yun H S, Kim Y S, Ahn J W
J Toxicol Clin Toxicol. 1984 Jul;22(1):77-85. doi: 10.3109/00099308409035083.
Aucubin, an iridoid glucoside isolated from Aucuba japonica (Cornaceae), exhibited significant protective activity against alpha-amanitin intoxication in mice. When a single dose of aucubin was administered intraperitoneally, a 50% survival rate was obtained even when the treatment was withheld for 12 hr after alpha-amanitin administration. A possible mechanism of protective activity is partly due to a competitive effect of aucubin on alpha-amanitin inhibition of liver RNA biosynthesis.
桃叶珊瑚苷是从山茱萸科植物东瀛珊瑚中分离得到的一种环烯醚萜苷，对小鼠α-鹅膏蕈碱中毒具有显著的保护活性。当腹腔注射单剂量桃叶珊瑚苷时，即使在给予α-鹅膏蕈碱12小时后停止治疗，仍可获得50%的存活率。其保护活性的一种可能机制部分归因于桃叶珊瑚苷对α-鹅膏蕈碱抑制肝脏RNA生物合成的竞争作用。
