Chang I M
Natural Products Research Institute and Graduate Studies in Natural Products Science, Seoul National University, Korea.
Res Commun Mol Pathol Pharmacol. 1998 Nov;102(2):189-204.
The iridoid glycosides including aucubin (AU), catalpol (CA), swertimarin (SW), and gardenoside (GA) are frequently found as natural constituents of many traditional oriental medicinal plants including Chinese herbs. Among these iridoid glycosides, AU was systematically studied for its potent liver-protective activities using experimental systems of hepatic damage. AU showed high liver-protective activity against carbon tetrachloride-induced hepatic damage in mice. Also AU showed significant protective activity against alpha-amanitin-induced hepatic damage in mice, and it prevented a depression of liver RNA biosynthesis caused by alpha-amanitin administration. Potent antidotal effects on mushroom poisoning in beagle dogs ingested with aqueous extract of Amanita virosa was observed; beagle dogs completely survived, even when AU administration was withheld for half an hour after mushroom poisoning. In addition, AU was found to suppress hepatitis B viral DNA replication in vitro. Conversion of AU to its aglycone form appeared to be a prerequisite step for an exhibition of such antiviral activity.
环烯醚萜苷类化合物，包括桃叶珊瑚苷（AU）、梓醇（CA）、獐牙菜苦苷（SW）和栀子苷（GA），常作为许多传统东方药用植物（包括中草药）的天然成分被发现。在这些环烯醚萜苷类化合物中，利用肝损伤实验系统对AU的强大肝脏保护活性进行了系统研究。AU对小鼠四氯化碳诱导的肝损伤具有很高的肝脏保护活性。此外，AU对小鼠α-鹅膏毒肽诱导的肝损伤也表现出显著的保护活性，并且它能防止因给予α-鹅膏毒肽而导致的肝脏RNA生物合成抑制。观察到对摄入毒蝇伞水提取物的比格犬的蘑菇中毒有强大的解毒作用；即使在蘑菇中毒后半小时停止给予AU，比格犬也完全存活。此外，发现AU在体外可抑制乙型肝炎病毒DNA复制。AU转化为其苷元形式似乎是展现这种抗病毒活性的一个先决步骤。
