Sugimachi K, Inokuchi K, Kai H, Ueo H, Kuwano H, Matsufuji H
J Surg Oncol. 1984 Nov;27(3):199-204. doi: 10.1002/jso.2930270315.
We prescribed hyperthermo-chemo-radiotherapy preoperatively for 13 patients with esophageal carcinoma. Viable cancer cells disappeared in four out of 13 patients, and all of these four patients survive without recurrence 3 to 34 postoperative months, at this writing. In another seven out of the 13, cancer cells were extensively damaged, despite the presence of a small number of viable cancer cells, and three out of these seven died with a recurrence. For two, the treatment was ineffective, and they died of liver metastasis and a local recurrence, respectively. These findings suggest that preoperative hyperthermia combined with chemotherapy and radiation is highly effective for treatment of carcinoma of the esophagus.
我们对13例食管癌患者进行了术前热化疗放疗。13例患者中有4例的存活癌细胞消失，截至撰写本文时，这4例患者均存活且术后3至34个月无复发。在另外7例患者中，尽管仍有少量存活癌细胞，但癌细胞受到广泛损伤，这7例中有3例死于复发。有2例治疗无效，分别死于肝转移和局部复发。这些结果表明，术前热疗联合化疗和放疗对食管癌治疗非常有效。
