Yachnis A T, Crawley J N, Jensen R T, McGrane M M, Moody T W
Life Sci. 1984 Nov 5;35(19):1963-9. doi: 10.1016/0024-3205(84)90477-6.
The ability of substance P analogues to inhibit the action of bombesin in the CNS was investigated using receptor binding and biological assays. The putative substance P antagonists inhibited binding to central receptors for both substance P and bombesin-like peptides. Spantide, which was the most potent analogue tested, reversed the bombesin induced hypothermia and grooming. Therefore the putative substance P antagonists may also antagonize the actions of bombesin in the CNS.
使用受体结合和生物学测定法研究了P物质类似物抑制蛙皮素在中枢神经系统中作用的能力。推定的P物质拮抗剂抑制了P物质和蛙皮素样肽与中枢受体的结合。Spantide是所测试的最有效的类似物，它逆转了蛙皮素诱导的体温过低和修饰行为。因此，推定的P物质拮抗剂也可能拮抗蛙皮素在中枢神经系统中的作用。
