Moody T W, Merali Z, Crawley J N
Department of Biochemistry, George Washington University, School of Medicine and Health Sciences, Washington, D. C. 20037.
Ann N Y Acad Sci. 1988;525:281-90. doi: 10.1111/j.1749-6632.1988.tb38613.x.
BN and other peptides increase grooming activity in rodents. This increase in grooming activity caused by BN can be reversed by numerous agents. The most direct of these are BN receptor antagonists such as spantide and [D-Phe-12]BN. These agents reverse the increase in grooming activity caused by BN and inhibit binding to central BN receptors. The increase in grooming activity caused by BN may be mediated by other neurotransmitters, such as dopamine. In this regard the increase in grooming activity caused by BN is reversed by fluphenazine and haloperidol. These agents do not affect binding to central BN receptors. Similarly, the increase in grooming caused by BN is absent if dopamine-containing neurons are lesioned with 6-OHDA. These lesions cause a significant reduction in central BN receptors, especially in the central amygdaloid nucleus. Thus some of the BN receptors may be present on dopamine-containing neurons. The increase in grooming activity caused by BN was also reversed by diazepam and chlordiazepoxide. Neither of these agents affected binding to central BN receptors, and similarly, BN did not affect binding to central benzodiazepine receptors. Thus anxiolytics may act at a site anatomically downstream from the BN receptor and reduce the apparent stress caused by central injection of BN.
促肾上腺皮质激素释放因子（BN）及其他肽类可增加啮齿动物的梳理行为。由BN引起的这种梳理行为增加可被多种药物逆转。其中最直接的是BN受体拮抗剂，如spantide和[D - Phe - 12]BN。这些药物可逆转由BN引起的梳理行为增加，并抑制与中枢BN受体的结合。由BN引起的梳理行为增加可能由其他神经递质介导，如多巴胺。在这方面，由BN引起的梳理行为增加可被氟奋乃静和氟哌啶醇逆转。这些药物不影响与中枢BN受体的结合。同样，如果用6 - 羟基多巴胺（6 - OHDA）损伤含多巴胺的神经元，由BN引起的梳理行为增加就会消失。这些损伤会导致中枢BN受体显著减少，尤其是在中央杏仁核。因此，一些BN受体可能存在于含多巴胺的神经元上。由BN引起的梳理行为增加也可被地西泮和氯氮卓逆转。这两种药物都不影响与中枢BN受体的结合，同样，BN也不影响与中枢苯二氮䓬受体的结合。因此，抗焦虑药可能作用于BN受体在解剖学上的下游位点，并减轻由中枢注射BN引起的明显应激。
