非波动性进行性肌张力障碍的治疗：一种神经药理学方法。

Treatment of non-fluctuating progressive dystonia: a neuropharmacological approach.

作者信息

Willemse J, van Nieuwenhuizen O, Gooskens R H, Westenberg H G

出版信息

Neuropediatrics. 1984 Oct;15(4):208-10. doi: 10.1055/s-2008-1052368.

DOI:10.1055/s-2008-1052368

PMID:6208504

Abstract

HVA and 5-HIAA in CSF were determined in five patients with non-fluctuating progressive dystonia before and after treatment with L-Dopa. The response to L-Dopa was unequivocally favourable in one patient. The HVA-level in her CSF was significantly reduced before treatment, whereas in the other four non-responding patients the pre-treatment HVA was normal. It is postulated, that the biochemical delineation of clinical responsiveness to a neurotransmitter may provide useful clues towards the classification of extrapyramidal disease in childhood.

摘要

在五名患有非波动性进行性肌张力障碍的患者中，在左旋多巴治疗前后测定了脑脊液中的高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）。一名患者对左旋多巴的反应明确良好。治疗前她脑脊液中的HVA水平显著降低，而其他四名无反应的患者治疗前HVA水平正常。据推测，对神经递质临床反应性的生化描述可能为儿童锥体外系疾病的分类提供有用线索。