Breuning M H, Breur B S, Engelsma M Y, Goulmy E, Iványi P
Tissue Antigens. 1984 Aug;24(2):90-7. doi: 10.1111/j.1399-0039.1984.tb02111.x.
We compared five cytotoxic T lymphocytes raised by primary mixed lymphocyte cultures of HLA-A, -B and -C serologically identical Bw35-positive responder-stimulator combinations. When tested on a panel of third-party target cells, the reactivity pattern of these cytotoxic T lymphocytes allowed the distinction of three subtypes of HLA-Bw35. Cold-target inhibition experiments and analysis of CTL activity at the clonal level showed the existence of subsets of CTLs directed against distinct antigenic determinants associated with HLA-Bw35.
我们比较了由 HLA - A、- B 和 - C 血清学相同的 Bw35 阳性反应者 - 刺激者组合的初次混合淋巴细胞培养产生的五种细胞毒性 T 淋巴细胞。当在一组第三方靶细胞上进行测试时，这些细胞毒性 T 淋巴细胞的反应模式能够区分 HLA - Bw35 的三种亚型。冷靶抑制实验和克隆水平的 CTL 活性分析表明，存在针对与 HLA - Bw35 相关的不同抗原决定簇的 CTL 亚群。
