Eroschenko V P, Becker G M
Toxicology. 1984 Oct;33(1):19-32. doi: 10.1016/0300-483x(84)90013-1.
Groups of sexually immature Japanese quail females, kept in a reduced photoperiod, received either daily intraperitoneal injections of 40 micrograms estradiol-17 beta for 26 days or were fed diets containing 0, 10, 40, 80 or 160 ppm chlordecone for the same duration. Estradiol-17 beta induced rapid cellular hypertrophy, cytodifferentiation, tubular gland formation, organelle proliferation and secretory granule formation in different cells of the quail oviduct. Higher chlordecone doses mimicked these estradiol-17 beta actions, but in addition induced atypical cell and organelle morphology, such as protruding or swollen cell apices, increased mitochondrial volume densities and diameters and disorganized Golgi apparati. The possible effects of these chlordecone-induced atypical cell alterations on avian reproduction are discussed.
将处于短光照周期的未达性成熟阶段的日本鹌鹑雌性群体，连续26天每日腹腔注射40微克的17β-雌二醇，或在相同时间段内饲喂含有0、10、40、80或160 ppm开蓬的日粮。17β-雌二醇诱导鹌鹑输卵管不同细胞出现快速的细胞肥大、细胞分化、管状腺形成、细胞器增殖和分泌颗粒形成。较高剂量的开蓬模拟了这些17β-雌二醇的作用，但除此之外还诱导了非典型的细胞和细胞器形态，如细胞顶端突出或肿胀、线粒体体积密度和直径增加以及高尔基体紊乱。本文讨论了这些开蓬诱导的非典型细胞改变对鸟类繁殖可能产生的影响。
