Khansur T, Little D, Tavassoli M
Arch Intern Med. 1984 Nov;144(11):2267. doi: 10.1001/archinte.144.11.2267.
We encountered a case of fulminant and fatal angioedema involving skin and lungs. This reaction, hitherto unreported, occurred 48 hours after termination of a course of bleomycin sulfate. It was not predictable by skin testing, nor was it reversible with steroid therapy. The only predictive clue was the development of eosinophilia during the course of therapy. Fulminant angioedema should be added to the list of potential reactions to bleomycin.
我们遇到了一例累及皮肤和肺部的暴发性致死性血管性水肿病例。这种反应此前未见报道，发生在硫酸博来霉素疗程结束后48小时。皮肤试验无法预测该反应，类固醇治疗也无法使其逆转。唯一的预测线索是治疗过程中出现嗜酸性粒细胞增多。暴发性血管性水肿应被列入博来霉素潜在反应的清单中。
