Kurnjek M L, Basso N, Taquini A C
Arch Int Physiol Biochim. 1984 Aug;92(2):53-63. doi: 10.3109/13813458409071127.
The total norepinephrine (NE) content, the uptake of [3H]NE, the turnover rate and the synthesis rate of the neurotransmitter at the heart and blood vessels have been studied during the development of hypertension in rats subjected to bilateral renal infarction. Normal and sham-operated rats were used as controls. Fifty percent of the rats with renal infarction became hypertensive. The weight of the hearts and blood vessels of the experimental animals was significantly increased 15 days after renal infarction. Changes were greater in hypertensive animals. NE concentration in the heart was slightly decreased without achieving statistical significance, while total NE content was unchanged. In the artery wall NE concentration was significantly decreased in normotensive and hypertensive operated rats. [3H]NE uptake in the heart and blood vessels was similar in experimental and control animals. In relation to NE turnover, in both the heart and blood vessels, normal and sham-operated animals behaved as one population while normotensive and hypertensive rats behaved as another population. The rate constant of NE turnover was increased in both tissues of operated experimental animals without achieving statistical significance in the case of the heart. NE synthesis rate was unchanged in the cardiac muscle but was significantly increased in the blood vessels of operated animals. Present data indicate that results describing NE dynamics in the heart cannot be extrapolated for the blood vessels level; on the other hand changes in the neurotransmitter do not seem to be related to the development of high blood pressure after renal infarction in the rat.
在双侧肾梗死大鼠高血压发展过程中，对心脏和血管中去甲肾上腺素（NE）的总量、[3H]NE摄取、神经递质的周转率和合成率进行了研究。正常大鼠和假手术大鼠作为对照。50%的肾梗死大鼠出现高血压。肾梗死后15天，实验动物的心脏和血管重量显著增加。高血压动物的变化更大。心脏中的NE浓度略有下降，但未达到统计学显著性，而NE总量未改变。在动脉壁中，正常血压和高血压手术大鼠的NE浓度均显著降低。实验动物和对照动物心脏和血管中[3H]NE的摄取相似。关于NE周转率，在心脏和血管中，正常大鼠和假手术动物表现为一个群体，而正常血压和高血压大鼠表现为另一个群体。手术实验动物的两个组织中NE周转率的速率常数均增加，但心脏情况未达到统计学显著性。心肌中的NE合成率未改变，但手术动物血管中的NE合成率显著增加。目前的数据表明，描述心脏中NE动力学的结果不能外推至血管水平；另一方面，神经递质的变化似乎与大鼠肾梗死后高血压的发展无关。
