Kurnjek M L, Basso N
Instituto de Investigaciones Cardiológicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
Clin Exp Hypertens. 1994 Jul;16(4):451-78. doi: 10.3109/10641969409067956.
The norepinephrine (NE) content, the uptake of [3H]NE, the turnover time, the turnover and the synthesis rate of the neurotransmitter in the heart and blood vessels were studied in the chronic phase of two kidney and one kidney Goldblatt renovascular hypertension, in the rat. Intact and sham operated animals were used as controls. Fifty percent of the rats subjected to renal clipping developed hypertension. This fact allowed us to compare changes in clip operated hypertensive and normotensive animals. The weight of the hearts and blood vessels was significantly increased in clip operated rats. Changes were greater in hypertensive animals. NE concentration and total content in the heart and in the artery wall were significantly decreased in the clipped rats. [3H]NE uptake was significantly diminished in the heart of experimental animals; in the artery wall, uptake was much lower than in the heart but no differences were observed between clip operated and sham animals. The turnover of NE was not different among control and clip operated rats either in the heart or in the blood vessels. Synthesis rate was lower in hypertensive animals than in their respective controls, explaining the lower concentration of the amine in cardiovascular tissues. The present data do not suggest that an increased turnover of NE in the cardiovascular sympathetic nerve endings is involved in the maintenance of high blood pressure in both types of Goldblatt renovascular hypertension.
在大鼠双侧肾血管性高血压和单侧肾血管性高血压的慢性期，研究了心脏和血管中去甲肾上腺素（NE）的含量、[3H]NE的摄取、周转时间、周转率以及神经递质的合成率。完整动物和假手术动物作为对照。接受肾动脉夹闭的大鼠中有50%出现高血压。这一事实使我们能够比较夹闭手术的高血压动物和正常血压动物的变化。夹闭手术大鼠的心脏和血管重量显著增加。高血压动物的变化更大。夹闭大鼠心脏和动脉壁中的NE浓度和总量显著降低。实验动物心脏中[3H]NE的摄取显著减少；在动脉壁中，摄取比心脏低得多，但夹闭手术动物和假手术动物之间未观察到差异。对照组和夹闭手术大鼠心脏或血管中NE的周转率没有差异。高血压动物的合成率低于各自的对照组，这解释了心血管组织中胺浓度较低的原因。目前的数据并不表明心血管交感神经末梢中NE周转率的增加与两种类型的Goldblatt肾血管性高血压的高血压维持有关。
