氯尼达明对潜在致死性损伤恢复的抑制作用。
Inhibition of the recovery from potentially lethal damage by lonidamine.
作者信息
Hahn G M, van Kersen I, Silvestrini B
出版信息
Br J Cancer. 1984 Nov;50(5):657-60. doi: 10.1038/bjc.1984.232.
Abstract
Lonidamine [1-(2,4-dichlorobenzyl)-1-H-indazol-3-carboxylic acid] is shown to inhibit recovery from potentially lethal damage after exposure of cells to X-rays, methyl methane sulfonate, or bleomycin and heat (43 degrees C, 1h). Inhibition is most effective when the drug is present before and after exposure of 10 to 25 mg l-1, a concentration readily achievable in vivo.
摘要
氯尼达明[1-(2,4-二氯苄基)-1-H-吲唑-3-羧酸]已被证明可抑制细胞在受到X射线、甲基磺酸甲酯或博来霉素及热（43摄氏度，1小时）照射后从潜在致死性损伤中恢复。当药物在暴露前后以10至25毫克/升的浓度存在时，抑制效果最为显著，该浓度在体内很容易达到。
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Studies of "potentially lethal damage" in EMT6 mouse tumour cells treated with bleomycin either in vitro or in vivo.关于博来霉素在体外或体内处理EMT6小鼠肿瘤细胞时“潜在致死性损伤”的研究。
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