Sewing K F, Hagie L, Ippoliti A F, Isenberg J I, Samloff I M, Sturdevant R A
Gastroenterology. 1978 Feb;74(2 Pt 2):276-9.
The inhibitory effects of cimetidine on gastric acid and pepsin secretion were studied before and after 1 month of treatment with 300 mg of cimetidine four times a day in 15 male duodenal ulcer patients. Cimetidine inhibited both pentagastrin- and peptone meal-stimulated acid secretion significantly better before, than after, 1 month of treatment. Similarly cimetidine inhibited pentagastrin-stimulated pepsin secretion significantly better before treatment. Meal-stimulated serum gastrin concentrations were significantly higher after treatment. The mechanism(s) of these effects was not apparent.
在15名男性十二指肠溃疡患者中，研究了西咪替丁对胃酸和胃蛋白酶分泌的抑制作用，这些患者每天4次服用300毫克西咪替丁，治疗1个月前后进行了对比。与治疗1个月后相比，治疗前西咪替丁对五肽胃泌素和蛋白胨餐刺激的胃酸分泌的抑制作用明显更好。同样，治疗前西咪替丁对五肽胃泌素刺激的胃蛋白酶分泌的抑制作用也明显更好。治疗后餐刺激的血清胃泌素浓度显著升高。这些作用的机制尚不清楚。
