Fedeli G, Anti M, Rapaccini G L, De Vitis I, Butti A, Civello I M
Dig Dis Sci. 1979 Oct;24(10):758-62. doi: 10.1007/BF01317208.
The authors report the results of a randomized study in which comparison was made between two different kinds of treatment in patients affected by uncomplicated duodenal ulcer endoscopically diagnosed. The first group was treated with 1 g of cimetidine per day, during a period of four weeks (200 mg three times a day and 400 mg at bedtime); the second with a liquid Al-Mg antacid compound, 210 ml/day 30 ml, 1 and 3 hr after meals and 30 ml before bedtime) for four weeks. Fity-one patients were studied, 27 treated with cimetidine, 24 with antacids. At the end of the four-week period, 21 patients (77.7%) in the cimetidine group and 18 patients (75%) in the antacid group were completely healed. Benign side effects were remarked in both types of treatment, none of which made it necessary to suspend treatment. No significant variation of the basal and peak acid output before and after each kind of treatment was observed, while a slight but significant increase in fasting serum gastrin concentration was noted after treatment in the antacid group.
作者报告了一项随机研究的结果，该研究对内镜诊断为单纯性十二指肠溃疡的患者的两种不同治疗方法进行了比较。第一组患者每天服用1克西咪替丁，为期四周（每日三次，每次200毫克，睡前服用400毫克）；第二组患者服用液体铝镁抗酸化合物，每天210毫升（餐后1小时和3小时各30毫升，睡前30毫升），为期四周。共研究了51例患者，27例接受西咪替丁治疗，24例接受抗酸剂治疗。在四周治疗期结束时，西咪替丁组21例患者（77.7%）完全愈合，抗酸剂组18例患者（75%）完全愈合。两种治疗方法均出现了良性副作用，但均未导致治疗中断。每种治疗前后的基础胃酸分泌量和高峰胃酸分泌量均未观察到显著变化，而抗酸剂组治疗后空腹血清胃泌素浓度有轻微但显著的升高。
