Ho M, Pazin G J, Armstrong J A, Haverkos H S, Dummer J S, Jannetta P J
J Infect Dis. 1984 Dec;150(6):867-72. doi: 10.1093/infdis/150.6.867.
Fifty-five patients undergoing microvascular decompression for trigeminal neuralgia were divided into three groups in a two-stage placebo-controlled study. All groups received two injections a day for five days beginning the day before surgery. Twenty-one patients received 10 placebo injections, 11 in the presurgical treatment group received three injections of 3.5 X 10(4) units of leukocyte interferon/kg before surgery, and 23 in the postsurgical treatment group received seven injections after surgery. The remaining injections in the two treatment groups were placebos. In the first stage, with 30 patients, 91% of the presurgical treatment group had reactivated oral herpesvirus infections (manifested by herpetic lesions and/or oral viral shedding) significantly more often than did concurrent controls (P less than .05). In the second stage, only the postsurgical treatment and placebo groups were studied, with no difference in reactivation of herpesvirus infection between the postsurgical treatment and placebo groups. Thus presurgical treatment with interferon alone may actually precipitate and accentuate herpesvirus infection.
在一项两阶段的安慰剂对照研究中，55例接受三叉神经痛微血管减压术的患者被分为三组。所有组从手术前一天开始，每天注射两次，共注射五天。21例患者接受10次安慰剂注射，术前治疗组的11例患者在手术前接受三次注射，剂量为3.5×10⁴单位白细胞干扰素/千克，术后治疗组的23例患者在手术后接受七次注射。两个治疗组的其余注射均为安慰剂。在第一阶段，30例患者中，术前治疗组91%的患者口腔疱疹病毒感染复发（表现为疱疹性病变和/或口腔病毒脱落）的频率明显高于同期对照组（P<0.05）。在第二阶段，仅对术后治疗组和安慰剂组进行研究，术后治疗组和安慰剂组之间疱疹病毒感染复发情况无差异。因此，单独术前使用干扰素治疗实际上可能会引发并加重疱疹病毒感染。
