干扰素预防生殖器疱疹复发。
Interferon in the prevention of genital herpes recurrence.
作者信息
Eron L J, Harvey L, Toy C, Santomauro D
出版信息
Antimicrob Agents Chemother. 1986 Oct;30(4):608-10. doi: 10.1128/AAC.30.4.608.
Abstract
Patients with genital herpes were treated three times weekly for 12 weeks with 3 X 10(6) IU of alpha 2b interferon (20 patients) or placebo (17 patients) administered by subcutaneous injection in a double-blind trial. Interferon had minimal effects on the suppression of recurrences and moderate toxicity (chills, fever, fatigue, and leukopenia), suggesting that this route and dosage of interferon may not be clinically useful for this indication.
摘要
在一项双盲试验中，生殖器疱疹患者每周接受三次治疗，为期12周，20名患者皮下注射3×10(6)国际单位的α2b干扰素，17名患者注射安慰剂。干扰素对复发的抑制作用极小，且有中度毒性（寒战、发热、疲劳和白细胞减少），这表明这种干扰素给药途径和剂量对该适应症可能无临床应用价值。
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