Messing E M, Bubbers J E, Dekernion J B, Fahey J L
J Urol. 1984 Dec;132(6):1230-4. doi: 10.1016/s0022-5347(17)50111-1.
Growth promoting properties have been identified in the conditioned serum-free medium from cultures of the human transitional cell carcinoma cell line 647V. This activity appears to reside in a molecule of more than 5000 MW. The factor responsible for 647V growth is distinguished from epidermal growth factor, since it fails to inhibit the specific binding of epidermal growth factor by 647V cells, and 647V cells are not stimulated to grow by epidermal growth factor. It also does not appear to be an insulin-like growth factor-like molecule since it fails to competitively bind with human insulin-like growth factor-carrier protein.
在人移行细胞癌细胞系647V培养的无血清条件培养基中已鉴定出生长促进特性。这种活性似乎存在于一个分子量超过5000的分子中。负责647V生长的因子与表皮生长因子不同，因为它不能抑制647V细胞对表皮生长因子的特异性结合，并且表皮生长因子也不能刺激647V细胞生长。它似乎也不是胰岛素样生长因子样分子，因为它不能与人胰岛素样生长因子载体蛋白竞争性结合。
