Müller-Jensen A
Fortschr Med. 1978 Jan 5;96(1):27-31.
With a modified method of infrared pupillography--especially developed for the use in clinical neurological routine diagnosis--the time course of the direct phasic pupillary light reflex in man was investigated under physiological and pathological conditions. The described method allows a high resolution of the time course of the light reflex and is superior to kinematographic as well as video-methods described so far. Normally the physiological time parameters are bilaterally symmetrical, also in cases of so-called physiological anisocoria. On the other hand in pathological anisocorias of various etiology pronounced side-differences and abnormal time parameters can be found. Also in cases of isocoria with clinically no abnormal findings of pupillomotor response pathological side-differences can be determined by infrared pupillography. Disturbances of the afferent arc, of the efferent arc and of combination of those as well as pupillary abnormalities to be located in the midbrain area, can be exactly analyzed and documented. Furthermore the method allows an objective documentation of the course in cases of dysfunction of the autonomic nervous system, like in intoxications, or to monitor drug-induced therapeutical measurements. The investigations and findings indicate that infrared pupillography, an objective method for analyzing the dynamics of the pupillary light reflex, is suitable for clinical neurological routing diagnosis.
采用一种专门为临床神经学常规诊断而开发的改良红外瞳孔描记法，研究了人体在生理和病理条件下直接相性瞳孔光反射的时间进程。所描述的方法能够高分辨率地显示光反射的时间进程，优于迄今为止所描述的运动学方法和视频方法。正常情况下，生理时间参数在双侧是对称的，所谓生理性瞳孔不等大的情况也是如此。另一方面，在各种病因导致的病理性瞳孔不等大中，可以发现明显的双侧差异和异常的时间参数。在瞳孔等大且瞳孔运动反应临床无异常发现的情况下，红外瞳孔描记法也可确定病理性双侧差异。传入弧、传出弧及其组合的干扰以及位于中脑区域的瞳孔异常，都可以得到精确分析和记录。此外，该方法还可以客观记录自主神经系统功能障碍的情况，如中毒时的情况，或监测药物诱导的治疗措施。研究结果表明，红外瞳孔描记法作为一种分析瞳孔光反射动力学的客观方法，适用于临床神经学常规诊断。
