Thom H, Buckland C M, Campbell A G, Thompson B, Farr V
Prenat Diagn. 1984 Sep-Oct;4(5):341-6. doi: 10.1002/pd.1970040504.
Maternal serum alpha-fetoprotein (MSAFP) values in the second trimester have been related to pregnancy outcome for 100 normal twin pairs, 42 monozygous (MZ) and 58 dizygous (DZ), liveborn after 28 weeks gestation. The median MSAFP value was 1.9 multiples of the median value (MOM) for uncomplicated singleton pregnancies. Both very low and very high MSAFP values were associated with twins of low birthweight. MSAFP values were higher in MZ than DZ twin pregnancies particularly those with dizygotes of like-sex. This effect was even more marked when only dichorionic like-sex twin pairs were compared.
孕中期母体血清甲胎蛋白（MSAFP）值与100对正常双胞胎的妊娠结局相关，这100对双胞胎为28周妊娠后出生的活产双胞胎，其中42对为单卵双胎（MZ），58对为双卵双胎（DZ）。对于无并发症的单胎妊娠，MSAFP值的中位数为中位数倍数（MOM）的1.9倍。极低和极高的MSAFP值均与低出生体重双胞胎有关。MZ双胎妊娠的MSAFP值高于DZ双胎妊娠，尤其是那些双卵双胎为同性别的情况。当仅比较双绒毛膜同性别的双胞胎对时，这种效应更为明显。
