多胎妊娠中的血清甲胎蛋白

Serum alphafetoprotein in multiple pregnancy.

作者信息

Bryan E M, Thorp R W, Nicholson E

出版信息

Biol Neonate. 1978;34(1-2):40-7. doi: 10.1159/000241103.

Abstract

The concentration of alpha-fetoprotein (AFP) was determined in paired umbilical cord and maternal sera in 42 multiple pregnancies. No concentrations above 1.4 microgram/ml were detected in maternal sera. Although there was a significant inverse correlation between cord AFP levels and gestational age, large intrapair discrepancies were common and these were not influenced by birth order, weight, or malformations. Intrapair AFP ratios were higher amongst dizygotic (DZ) than monozygotic (MZ) twins. In a pair discordant for neonatal hepatitis, the affected twin had the lower level of AFP in cord serum, but AFP was still detectable at 55 days.

摘要

对42例多胎妊娠的脐带血和母血配对样本测定了甲胎蛋白（AFP）浓度。母血中未检测到浓度高于1.4微克/毫升的情况。尽管脐带AFP水平与孕周之间存在显著的负相关，但配对样本中差异较大的情况很常见，且不受出生顺序、体重或畸形的影响。双卵双胎（DZ）的配对AFP比值高于单卵双胎（MZ）。在一对患新生儿肝炎的不一致样本中，患病胎儿的脐带血清中AFP水平较低，但在55天时仍可检测到AFP。