Handelmann G E, Selsky J H, Helke C J
Physiol Behav. 1984 Aug;33(2):297-300. doi: 10.1016/0031-9384(84)90115-x.
Substance P (SP) administered subcutaneously to neonatal rats on days 1-7 after birth produced long-term physiological changes. The changes included altered pain perception and increased sialogogic response to SP, although the hypotensive response to SP was unchanged. Early exposure to the peptide therefore influenced development, particularly with respect to two systems in which SP is physiologically active. Both changes may reflect an increased sensitivity of these systems to the effects of SP.
出生后1 - 7天对新生大鼠皮下注射P物质（SP）会产生长期的生理变化。这些变化包括痛觉改变以及对SP的唾液分泌反应增加，尽管对SP的降压反应未变。因此，早期接触该肽会影响发育，特别是在SP具有生理活性的两个系统方面。这两种变化可能反映了这些系统对SP作用的敏感性增加。
