• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

γ-前速激肽原-(72-92)-肽酰胺增强P物质诱导的唾液分泌。

gamma-Preprotachykinin-(72-92)-peptide amide potentiates substance P-induced salivation.

作者信息

Takeda Y, Krause J E

机构信息

Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110.

出版信息

Eur J Pharmacol. 1989 Feb 28;161(2-3):267-71. doi: 10.1016/0014-2999(89)90858-3.

DOI:10.1016/0014-2999(89)90858-3
PMID:2470599
Abstract

The effects of gamma-preprotachykinin-(72-92)-peptide amide [gamma-PPT-(72-92)-NH2] on salivation in the rat were investigated and were compared with salivation responses elicited by a variety of other tachykinin and related peptides. On intravenous injection or continuous infusion, gamma-PPT-(72-92)-NH2, a naturally occurring N-terminally extended derivative of neurokinin A (NKA), potently stimulated salivation. The rank order of potency of peptides that stimulated salivation was: NPK greater than gamma-PPT-(72-92)-NH2 greater than substance P greater than NKA = Asp-Ala-NKA. Moreover, gamma-PPT-(72-92)-NH2, like NPK, potentiated the effects of substance P on salivary secretion. These results indicate that the actions of gamma-PPT-(72-92)-NH2 may be pharmacologically or physiologically relevant in the actions of tachykinin peptides.

摘要

研究了γ-前速激肽-(72 - 92)-肽酰胺[γ-PPT-(72 - 92)-NH2]对大鼠唾液分泌的影响，并将其与多种其他速激肽及相关肽引发的唾液分泌反应进行了比较。静脉注射或持续输注时，γ-PPT-(72 - 92)-NH2（一种天然存在的神经激肽A（NKA）N端延伸衍生物）能有效刺激唾液分泌。刺激唾液分泌的肽的效价顺序为：神经肽K大于γ-PPT-(72 - 92)-NH2大于P物质大于神经激肽A = 天冬酰胺-丙氨酸-神经激肽A。此外，γ-PPT-(72 - 92)-NH2与神经肽K一样，能增强P物质对唾液分泌的作用。这些结果表明，γ-PPT-(72 - 92)-NH2的作用在速激肽肽类的作用中可能具有药理学或生理学相关性。

相似文献

1
gamma-Preprotachykinin-(72-92)-peptide amide potentiates substance P-induced salivation.γ-前速激肽原-(72-92)-肽酰胺增强P物质诱导的唾液分泌。
Eur J Pharmacol. 1989 Feb 28;161(2-3):267-71. doi: 10.1016/0014-2999(89)90858-3.
2
Neuropeptide K potently stimulates salivary gland secretion and potentiates substance P-induced salivation.神经肽K能有效刺激唾液腺分泌，并增强P物质诱导的唾液分泌。
Proc Natl Acad Sci U S A. 1989 Jan;86(1):392-6. doi: 10.1073/pnas.86.1.392.
3
Diverse effects of tachykinins on luteinizing hormone release in male rats: mechanism of action.速激肽对雄性大鼠促黄体生成素释放的多种作用：作用机制
Endocrinology. 1992 Sep;131(3):1195-201. doi: 10.1210/endo.131.3.1380435.
4
Regional distribution of neuropeptide gamma and other tachykinin peptides derived from the substance P gene in the rat.大鼠中源自P物质基因的神经肽γ和其他速激肽肽的区域分布。
Regul Pept. 1990 May 21;28(3):323-33. doi: 10.1016/0167-0115(90)90030-z.
5
Effect of a novel tachykinin, substance K, on salivation in rats.一种新型速激肽（物质K）对大鼠唾液分泌的影响。
Eur J Pharmacol. 1985 May 20;111(3):381-3. doi: 10.1016/0014-2999(85)90646-6.
6
gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors.
Proc Natl Acad Sci U S A. 1990 Jan;87(1):246-50. doi: 10.1073/pnas.87.1.246.
7
The central pressor actions of a novel tachykinin peptide, gamma-preprotachykinin-(72-92)-peptide amide.一种新型速激肽肽，γ-前速激肽-(72-92)-肽酰胺的中枢升压作用。
Eur J Pharmacol. 1991 Jan 3;192(1):173-6. doi: 10.1016/0014-2999(91)90086-6.
8
Structure, expression, and some regulatory mechanisms of the rat preprotachykinin gene encoding substance P, neurokinin A, neuropeptide K, and neuropeptide gamma.编码P物质、神经激肽A、神经肽K和神经肽γ的大鼠前速激肽原基因的结构、表达及一些调控机制。
J Neurosci. 1990 Jul;10(7):2203-14. doi: 10.1523/JNEUROSCI.10-07-02203.1990.
9
Bronchoconstrictor activities of NP gamma and NPK in anaesthetized guinea-pigs: effect on NEP inhibition.NPγ和NPK在麻醉豚鼠中的支气管收缩活性：对中性内肽酶抑制的影响。
Pulm Pharmacol. 1993 Jun;6(2):143-7. doi: 10.1006/pulp.1993.1018.
10
Measurement of tachykinin-induced salivation in conscious rats.清醒大鼠中速激肽诱导唾液分泌的测量
J Pharmacol Methods. 1991 Aug;26(1):67-72. doi: 10.1016/0160-5402(91)90055-a.

引用本文的文献

1
Cardiovascular responses to intrathecal neuropeptide gamma in conscious rats: receptor characterization and mechanism of action.清醒大鼠鞘内注射神经肽γ后的心血管反应：受体特征及作用机制
Br J Pharmacol. 1996 Jan;117(2):250-7. doi: 10.1111/j.1476-5381.1996.tb15184.x.
2
Tachykinin NK1 receptor subtypes in the rat urinary bladder.大鼠膀胱中的速激肽NK1受体亚型
Br J Pharmacol. 1994 Mar;111(3):739-46. doi: 10.1111/j.1476-5381.1994.tb14800.x.
3
Characterization of a tachykinin peptide NK2 receptor transfected into murine fibroblast B82 cells.
转染至小鼠成纤维细胞B82中的速激肽肽NK2受体的特性研究。
Proc Natl Acad Sci U S A. 1991 Mar 1;88(5):1661-5. doi: 10.1073/pnas.88.5.1661.
4
gamma-Preprotachykinin-(72-92)-peptide amide: an endogenous preprotachykinin I gene-derived peptide that preferentially binds to neurokinin-2 receptors.
Proc Natl Acad Sci U S A. 1990 Jan;87(1):246-50. doi: 10.1073/pnas.87.1.246.
5
Comparison of the effects of neuropeptide K and neuropeptide gamma with neurokinin A at NK2 receptors in the hamster urinary bladder.在仓鼠膀胱中神经肽K、神经肽γ与神经激肽A对NK2受体作用的比较。
Naunyn Schmiedebergs Arch Pharmacol. 1992 Jan;345(1):51-6. doi: 10.1007/BF00175469.