Levy S, Tempe J L, Aleksijevic A, Giron C, Oberling F, Mayer S, Lang J M
Scand J Haematol. 1984 Oct;33(4):386-90. doi: 10.1111/j.1600-0609.1984.tb00712.x.
Natural killer (NK) cell activity of unseparated peripheral blood mononuclear cells from 30 untreated patients with Hodgkin's disease and 22 age- and sex-matched normal controls was evaluated using the classical K 562 cells as targets. A significant defect was demonstrated in the patients with stage I-II and seemed to be more profound in patients with advanced disease (stage III-IV) and in those with B symptoms. The differences between subgroups of patients, however, were not statistically significant, mostly because of the wide dispersion of individual data. Pre-incubation of effector cells with alpha A leucocyte recombinant interferon led to a clear increase in NK cell activity in 4 of 6 patients tested, showing that depressed NK activity in Hodgkin's disease is still susceptible to the enhancing effect of interferon, at least in some patients.
使用经典的K562细胞作为靶标，评估了30例未经治疗的霍奇金病患者及22例年龄和性别匹配的正常对照者未分离的外周血单个核细胞的自然杀伤（NK）细胞活性。I-II期患者存在显著缺陷，且似乎在晚期疾病（III-IV期）患者及有B症状的患者中更为明显。然而，患者亚组之间的差异无统计学意义，主要是因为个体数据的广泛离散。效应细胞与αA白细胞重组干扰素预孵育后，在检测的6例患者中有4例NK细胞活性明显增加，表明霍奇金病中NK活性降低至少在部分患者中仍易受干扰素增强作用的影响。
