Levy S, Tempé J L, Caussade P, Aleksijevic A, Grosshans E, Mayer S, Lang J M
Cancer Immunol Immunother. 1984;18(2):138-40. doi: 10.1007/BF00205749.
Natural killer activity of peripheral blood mononuclear cells against the human cell line K 562 was evaluated in 11 patients with mycosis fungoides and simultaneously in 10 age- and sex-matched controls. In the patient group, nine had no previous treatment and in two topical therapy had been discontinued more than 3 months before. None had any associated disease or concurrent therapy that could interfere with the immune system. Patients with early disease showed a mean specific lysis and a range of individual data similar to the controls whereas patients with advanced disease had a significant defect of natural killer activity at effector: target ratios of 100 : 1, 50 : 1, and 25 : 1, as shown by the Mann-Whitney test. Preincubation of effector cells with alpha-interferon for 1 h in a single patient with low natural killing capacity led to a clear increase of the specific lysis, suggesting reduced functional activity rather than depletion of effector cells.
在11例蕈样肉芽肿患者中评估了外周血单个核细胞对人细胞系K 562的自然杀伤活性，同时在10名年龄和性别匹配的对照者中进行了评估。在患者组中，9例未接受过治疗，2例在3个多月前已停止局部治疗。无一例有任何可能干扰免疫系统的相关疾病或同时进行的治疗。早期疾病患者表现出的平均特异性裂解和一系列个体数据与对照组相似，而晚期疾病患者在效应细胞与靶细胞比例为100:1、50:1和25:1时，自然杀伤活性存在显著缺陷，曼-惠特尼检验显示了这一点。在一名自然杀伤能力较低的患者中，效应细胞与α-干扰素预孵育1小时导致特异性裂解明显增加，提示效应细胞功能活性降低而非耗竭。
