Schwartz W J, Sharp F R
J Comp Neurol. 1978 Jan 15;177(2):335-59. doi: 10.1002/cne.901770210.
The 2-deoxy-D-[14C]-glucose (2-DG) autoradiographic method for determining regional brain glucose consumption has been applied successfully by a number of workers for mapping the alterations of brain glucose consumption which occur in association with experimental alterations of brain functional activity. This paper provides a framework for the interpretation of these and further studies by presenting: (1) the pattern of regional brain glucose consumption in the normal, resting, awake rat; (2) the anatomical identities of brain structures which on autoradiographs appear only as regional variations of optical density. For this purpose, a series of 2-DG autoradiographs of coronal brain sections from an injected animal is compared with adjacent labeled Nissl sections.
许多研究人员已成功应用2-脱氧-D-[14C]-葡萄糖（2-DG）放射自显影法来测定局部脑葡萄糖消耗，以绘制与脑功能活动的实验性改变相关的脑葡萄糖消耗变化图。本文通过呈现以下内容为这些研究及进一步研究的解释提供了一个框架：（1）正常、静息、清醒大鼠的局部脑葡萄糖消耗模式；（2）在放射自显影片上仅表现为光密度区域变化的脑结构的解剖学特征。为此，将一只注射动物的一系列冠状脑切片的2-DG放射自显影片与相邻的标记尼氏切片进行比较。
