血浆置换对系统性红斑狼疮患者T和B淋巴细胞功能的影响：一项双盲研究。
Effect of plasmapheresis on T anc B lymphocyte functions in patients with systemic lupus erythematosus: a double blind study.
作者信息
Tsokos G C, Balow J E, Huston D P, Wei N, Decker J L
出版信息
Clin Exp Immunol. 1982 May;48(2):449-57.
Nine patients with active systemic lupus erythematosus entered a double-blind randomized trial to study the therapeutic effect of vigorous versus sham reinfusion plasmapheresis. Four of them received real plasmapheresis while five received sham reinfusion plasmapheresis. In the present communication we report the effects of these procedures on T lymphocytes in peripheral mononuclear cells, proliferative response to mitogens, allogeneic mixed lymphocyte reaction and cell-mediated lympholysis, as well as the effect of plasmapheresis on the spontaneous and pokeweed mitogen induced immunoglobulin secreting cells in peripheral blood. Several mononuclear cell functions were abnormal at the beginning of the study but no significant changes related to plasmaphersis occurred in any of the parameters studied.
9例活动性系统性红斑狼疮患者进入一项双盲随机试验，以研究强化血浆置换与假性再输注血浆置换的治疗效果。其中4例接受了真正的血浆置换，5例接受了假性再输注血浆置换。在本报告中，我们阐述了这些操作对外周血单个核细胞中T淋巴细胞、对有丝分裂原的增殖反应、同种异体混合淋巴细胞反应和细胞介导的淋巴细胞溶解的影响，以及血浆置换对外周血中自发和由商陆有丝分裂原诱导的免疫球蛋白分泌细胞的影响。在研究开始时，几种单个核细胞功能异常，但在所研究的任何参数中，均未发生与血浆置换相关的显著变化。
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